Complement and the Alternative Pathway Play an Important Role in LPS/D-GalN-Induced Fulminant Hepatic Failure

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Sun, Shihui; Guo, Yan; Zhao, Guangyu; Zhou, Xiaojun; Li, Junfeng; Hu, Jingya; Yu, Hong; Chen, Yu; Song, Hongbin; Qiao, Fei; Xu, Guilian; Yang, Fei; Wu, Yuzhang; Tomlinson, Stephen; Duan, Zhongping; Zhou, Yusen;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 6,issue 11 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0026838, pmc: PMC3206060
  • Subject: Animal Models | Research Article | Biology | Immune Physiology | Gastroenterology and Hepatology | Complement System | Medicine | Anatomy and Physiology | Q | Mouse | R | Immunopathology | Model Organisms | Acute Liver Failure | Clinical Immunology | Science | Immune System | Liver Diseases | Immunology
    mesheuropmc: chemical and pharmacologic phenomena

Fulminant hepatic failure (FHF) is a clinically severe type of liver injury with an extremely high mortality rate. Although the pathological mechanisms of FHF are not well understood, evidence suggests that the complement system is involved in the pathogenesis of a vari... View more
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