Outer Electrospun Polycaprolactone Shell Induces Massive Foreign Body Reaction and Impairs Axonal Regeneration through 3D Multichannel Chitosan Nerve Guides

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Duda, Sven; Dreyer, Lutz; Behrens, Peter; Wienecke, Soenke; Chakradeo, Tanmay; Glasmacher, Birgit; Haastert-Talini, Kirsten;
  • Publisher: Hindawi Publishing Corporation
  • Journal: BioMed Research International,volume 2,014 (issn: 2314-6133, eissn: 2314-6141)
  • Related identifiers: doi: 10.15488/635, doi: 10.1155/2014/835269, pmc: PMC4000981
  • Subject: Chitosan | biomaterial | polycaprolactone | Microscopy, Electron, Scanning | electrophysiological procedures | Muscles | polyester | nerve fiber | extracellular space | Animals | Female | giant cell | scanning electron microscopy | Wistar rat | chemically induced | rat | peripheral nerve | nociception | drug effects | animal experiment | article | Motor Activity | Recovery of Function | Electrodiagnosis | animal | nonhuman | Biocompatible Materials | automutilation | adult | pathology | Research Article | tissue scaffold | nerve fiber regeneration | microenvironment | Axons | electrospinning | Inflammation | muscle | pathophysiology | procedures | Rats, Wistar | Nerve Regeneration | Article Subject | Tissue Scaffolds | freeze drying | Organ Size | foreign body reaction | in vivo study | Medicine | electric field | nerve transplantation | Foreign-Body Reaction | Polyesters | tissue regeneration | R | convalescence | controlled study | Pain Perception | Guided Tissue Regeneration | sciatic nerve
    • ddc: ddc:570 | ddc:610 | ddc:600
    mesheuropmc: technology, industry, and agriculture | equipment and supplies

We report on the performance of composite nerve grafts with an inner 3D multichannel porous chitosan core and an outer electrospun polycaprolactone shell. The inner chitosan core provided multiple guidance channels for regrowing axons. To analyze the in vivo properties ... View more
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