publication . Article . 2016

Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses

Li, Xiaoli; Li, Yaqing; Han, Gaoyang; Li, Xiaoran; Ji, Yasai; Fan, Zhirui; Zhong, Yali; Cao, Jing; Zhao, Jing; Mariusz, Goscinski; ...
  • Published: 08 Nov 2016
Abstract
// Xiaoli Li 1, 2 , Yaqing Li 1, 2 , Gaoyang Han 3 , Xiaoran Li 2 , Yasai Ji 1 , Zhirui Fan 1 , Yali Zhong 1 , Jing Cao 1, 4 , Jing Zhao 1 , Goscinski Mariusz 5 , Mingzhi Zhang 1 , Jianguo Wen 6 , Jahn M. Nesland 2 , Zhenhe Suo 1, 2 1 Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China 2 Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo, Montebello, Oslo, Norway 3 Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui City, Henan Province, China 4 Department of Pathology, The ...
Subjects
free text keywords: Oncology, Immunology, Biology, Mutation, medicine.disease_cause, medicine, Inner mitochondrial membrane, Gene, Mitochondrion, Mitochondrial pyruvate carrier 1, Gene knockout, Exon, Andrology, Genetics, Fatty acid, chemistry.chemical_classification, chemistry, Research Paper, MPC1, CRISPR/Cas9, diabetes, reproductive capability
40 references, page 1 of 3

McCommis, KS, Finck, BN. Mitochondrial pyruvate transport: a historical perspective and future research directions. Biochem J. 2015; 466: 443-54 [OpenAIRE] [PubMed] [DOI]

Divakaruni, AS, Wiley, SE, Rogers, GW, Andreyev, AY, Petrosyan, S, Loviscach, M, Wall, EA, Yadava, N, Heuck, AP, Ferrick, DA, Henry, RR, McDonald, WG, Colca, JR. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc Natl Acad Sci U S A. 2013; 110: 5422-7 [OpenAIRE] [PubMed] [DOI]

Gray, LR, Tompkins, SC, Taylor, EB. Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci. 2014; 71: 2577-604 [OpenAIRE] [PubMed] [DOI]

Papa, S, Francavilla, A, Paradies, G, Meduri, B. The transport of pyruvate in rat liver mitochondria. FEBS Lett. 1971; 12: 285-8 [OpenAIRE] [PubMed]

Halestrap, AP. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J. 1975; 148: 85-96 [OpenAIRE] [PubMed]

Brivet, M, Garcia-Cazorla, A, Lyonnet, S, Dumez, Y, Nassogne, MC, Slama, A, Boutron, A, Touati, G, Legrand, A, Saudubray, JM. Impaired mitochondrial pyruvate importation in a patient and a fetus at risk. Mol Genet Metab. 2003; 78: 186-92 [OpenAIRE] [PubMed]

Bricker, DK, Taylor, EB, Schell, JC, Orsak, T, Boutron, A, Chen, YC, Cox, JE, Cardon, CM, Van Vranken, JG, Dephoure, N, Redin, C, Boudina, S, Gygi, SP. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science. 2012; 337: 96-100 [OpenAIRE] [PubMed] [DOI]

Herzig, S, Raemy, E, Montessuit, S, Veuthey, JL, Zamboni, N, Westermann, B, Kunji, ER, Martinou, JC. Identification and functional expression of the mitochondrial pyruvate carrier. Science. 2012; 337: 93-6 [OpenAIRE] [PubMed] [DOI]

Colca, JR, McDonald, WG, Cavey, GS, Cole, SL, Holewa, DD, Brightwell-Conrad, AS, Wolfe, CL, Wheeler, JS, Coulter, KR, Kilkuskie, PM, Gracheva, E, Korshunova, Y, Trusgnich, M. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)–relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One. 2013; 8: e61551 [OpenAIRE] [PubMed] [DOI]

Li, CL, Wang, M, Ma, XY, Zhang, W. NRGA1, a putative mitochondrial pyruvate carrier, mediates ABA regulation of guard cell ion channels and drought stress responses in Arabidopsis. Mol. Plant. 2014; 7: 1508-21 [OpenAIRE] [PubMed] [DOI]

Rohatgi, N, Aly, H, Marshall, CA, McDonald, WG, Kletzien, RF, Colca, JR, McDaniel, ML. Novel insulin sensitizer modulates nutrient sensing pathways and maintains b-cell phenotype in human islets. PLoS One. 2013; 8: e62012 [OpenAIRE] [PubMed] [DOI]

Titheradge, MA, Coore, HG. Hormonal regulation of liver mitochondrial pyruvate carrier in relation to gluconeogenesis and lipogenesis. FEBS Lett. 1976; 72: 73-8 [OpenAIRE] [PubMed]

Titheradge, MA, Coore, HG. The mitochondrial pyruvate carrier, its exchange properties and its regulation by glucagon. FEBS Lett. 1976; 63: 45-50 [OpenAIRE] [PubMed]

McCommis, KS, Chen, Z, Fu, X, McDonald, WG, Colca, JR, Kletzien, RF, Burgess, SC, Finck, BN. Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling. Cell Metab. 2015; 22: 682-94 [OpenAIRE] [PubMed] [DOI]

Kelly, T, Yang, W, Chen, CS, Reynolds, K, He, J. Global burden of obesity in 2005 and projections to 2030. Int. J. Obes. (Lond). 2008; 32: 1431-7 [OpenAIRE] [PubMed] [DOI]

40 references, page 1 of 3
Abstract
// Xiaoli Li 1, 2 , Yaqing Li 1, 2 , Gaoyang Han 3 , Xiaoran Li 2 , Yasai Ji 1 , Zhirui Fan 1 , Yali Zhong 1 , Jing Cao 1, 4 , Jing Zhao 1 , Goscinski Mariusz 5 , Mingzhi Zhang 1 , Jianguo Wen 6 , Jahn M. Nesland 2 , Zhenhe Suo 1, 2 1 Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China 2 Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo, Montebello, Oslo, Norway 3 Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui City, Henan Province, China 4 Department of Pathology, The ...
Subjects
free text keywords: Oncology, Immunology, Biology, Mutation, medicine.disease_cause, medicine, Inner mitochondrial membrane, Gene, Mitochondrion, Mitochondrial pyruvate carrier 1, Gene knockout, Exon, Andrology, Genetics, Fatty acid, chemistry.chemical_classification, chemistry, Research Paper, MPC1, CRISPR/Cas9, diabetes, reproductive capability
40 references, page 1 of 3

McCommis, KS, Finck, BN. Mitochondrial pyruvate transport: a historical perspective and future research directions. Biochem J. 2015; 466: 443-54 [OpenAIRE] [PubMed] [DOI]

Divakaruni, AS, Wiley, SE, Rogers, GW, Andreyev, AY, Petrosyan, S, Loviscach, M, Wall, EA, Yadava, N, Heuck, AP, Ferrick, DA, Henry, RR, McDonald, WG, Colca, JR. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc Natl Acad Sci U S A. 2013; 110: 5422-7 [OpenAIRE] [PubMed] [DOI]

Gray, LR, Tompkins, SC, Taylor, EB. Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci. 2014; 71: 2577-604 [OpenAIRE] [PubMed] [DOI]

Papa, S, Francavilla, A, Paradies, G, Meduri, B. The transport of pyruvate in rat liver mitochondria. FEBS Lett. 1971; 12: 285-8 [OpenAIRE] [PubMed]

Halestrap, AP. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J. 1975; 148: 85-96 [OpenAIRE] [PubMed]

Brivet, M, Garcia-Cazorla, A, Lyonnet, S, Dumez, Y, Nassogne, MC, Slama, A, Boutron, A, Touati, G, Legrand, A, Saudubray, JM. Impaired mitochondrial pyruvate importation in a patient and a fetus at risk. Mol Genet Metab. 2003; 78: 186-92 [OpenAIRE] [PubMed]

Bricker, DK, Taylor, EB, Schell, JC, Orsak, T, Boutron, A, Chen, YC, Cox, JE, Cardon, CM, Van Vranken, JG, Dephoure, N, Redin, C, Boudina, S, Gygi, SP. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science. 2012; 337: 96-100 [OpenAIRE] [PubMed] [DOI]

Herzig, S, Raemy, E, Montessuit, S, Veuthey, JL, Zamboni, N, Westermann, B, Kunji, ER, Martinou, JC. Identification and functional expression of the mitochondrial pyruvate carrier. Science. 2012; 337: 93-6 [OpenAIRE] [PubMed] [DOI]

Colca, JR, McDonald, WG, Cavey, GS, Cole, SL, Holewa, DD, Brightwell-Conrad, AS, Wolfe, CL, Wheeler, JS, Coulter, KR, Kilkuskie, PM, Gracheva, E, Korshunova, Y, Trusgnich, M. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)–relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One. 2013; 8: e61551 [OpenAIRE] [PubMed] [DOI]

Li, CL, Wang, M, Ma, XY, Zhang, W. NRGA1, a putative mitochondrial pyruvate carrier, mediates ABA regulation of guard cell ion channels and drought stress responses in Arabidopsis. Mol. Plant. 2014; 7: 1508-21 [OpenAIRE] [PubMed] [DOI]

Rohatgi, N, Aly, H, Marshall, CA, McDonald, WG, Kletzien, RF, Colca, JR, McDaniel, ML. Novel insulin sensitizer modulates nutrient sensing pathways and maintains b-cell phenotype in human islets. PLoS One. 2013; 8: e62012 [OpenAIRE] [PubMed] [DOI]

Titheradge, MA, Coore, HG. Hormonal regulation of liver mitochondrial pyruvate carrier in relation to gluconeogenesis and lipogenesis. FEBS Lett. 1976; 72: 73-8 [OpenAIRE] [PubMed]

Titheradge, MA, Coore, HG. The mitochondrial pyruvate carrier, its exchange properties and its regulation by glucagon. FEBS Lett. 1976; 63: 45-50 [OpenAIRE] [PubMed]

McCommis, KS, Chen, Z, Fu, X, McDonald, WG, Colca, JR, Kletzien, RF, Burgess, SC, Finck, BN. Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling. Cell Metab. 2015; 22: 682-94 [OpenAIRE] [PubMed] [DOI]

Kelly, T, Yang, W, Chen, CS, Reynolds, K, He, J. Global burden of obesity in 2005 and projections to 2030. Int. J. Obes. (Lond). 2008; 32: 1431-7 [OpenAIRE] [PubMed] [DOI]

40 references, page 1 of 3
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publication . Article . 2016

Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses

Li, Xiaoli; Li, Yaqing; Han, Gaoyang; Li, Xiaoran; Ji, Yasai; Fan, Zhirui; Zhong, Yali; Cao, Jing; Zhao, Jing; Mariusz, Goscinski; ...