Independent recruitment of a flavin-dependent monooxygenase for safe accumulation of sequestered pyrrolizidine alkaloids in grasshoppers and moths.

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Wang, Linzhu; Beuerle, Till; Timbilla, James; Ober, Dietrich;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 7,issue 2 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3282741, doi: 10.1371/journal.pone.0031796
  • Subject: Molecular Genetics | Toxicology | Research Article | Biology | Enzymes | Medicine | Q | Ecology | R | Genetics | Biochemistry | Science | Metabolism | Enzyme Classes | Zoology
    mesheuropmc: endocrine system | complex mixtures | heterocyclic compounds | organic chemicals

Several insect lineages have developed diverse strategies to sequester toxic pyrrolizidine alkaloids from food-plants for their own defense. Here, we show that in two highly divergent insect taxa, the hemimetabolous grasshoppers and the holometabolous butterflies, an al... View more
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