publication . Article . Other literature type . 2017

Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

Willem J. M. Mulder; Max L. Senders; Hannah Groenen; Cuihua Wang; Jacob M. Hooker; Gabriel Courties; Filip K. Swirski; Carlos Pérez-Medina; Matthias Nahrendorf; Ralph Weissleder; ...
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Open Access English
  • Published: 16 Jan 2017
  • Publisher: Nature Publishing Group
  • Country: United States
Abstract
Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here we describe positron emission tomography (PET) imaging with 18F-Macroflor, a modified polyglucose nanoparticle with high avidity for macrophages. Due to its small size, Macroflor is excreted renally, a prerequisite for imaging with the isotope flourine-18. The particle's short blood half-life, measured in three species, including a primate, enables macrophage imaging in inflamed cardiovascular ti...
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doi: 10.1038/ncomms14064. , 10.1038/ncomms14064
pmc: PMC5241815
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Subjects
free text keywords: Article, Kidney, medicine.anatomical_structure, medicine, Heart failure, medicine.disease, Preclinical imaging, Pathology, medicine.medical_specialty, Inflammation, medicine.symptom, Immunology, Magnetic resonance imaging, medicine.diagnostic_test, Myocardial infarction, Avidity, Positron emission tomography
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Funded by
NIH| Anti-inflammatory nanoparticle formulations to treat atherosclerosis
Project
Anti-inflammatory nanoparticle formulations to treat atherosclerosis
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01HL118440-01A1
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
, NIH| MOUSE GENETICS
Project
MOUSE GENETICS
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
, NIH| Bioorthogonal Strategies for Targeted PET Imaging Probe Development
Project
Bioorthogonal Strategies for Targeted PET Imaging Probe Development
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1K25EB016673-01
  • Funding stream: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
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