publication . Article . Other literature type . 2017

Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

Willem J. M. Mulder; Max L. Senders; Hannah Groenen; Cuihua Wang; Jacob M. Hooker; Gabriel Courties; Filip K. Swirski; Carlos Pérez-Medina; Matthias Nahrendorf; Ralph Weissleder; ...
Open Access English
  • Published: 16 Jan 2017
  • Publisher: Nature Publishing Group
  • Country: United States
Abstract
Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here we describe positron emission tomography (PET) imaging with 18F-Macroflor, a modified polyglucose nanoparticle with high avidity for macrophages. Due to its small size, Macroflor is excreted renally, a prerequisite for imaging with the isotope flourine-18. The particle's short blood half-life, measured in three species, including a primate, enables macrophage imaging in inflamed cardiovascular ti...
Subjects
free text keywords: Article, Kidney, medicine.anatomical_structure, medicine, Heart failure, medicine.disease, Preclinical imaging, Pathology, medicine.medical_specialty, Inflammation, medicine.symptom, Immunology, Magnetic resonance imaging, medicine.diagnostic_test, Myocardial infarction, Avidity, Positron emission tomography
Funded by
NIH| Anti-inflammatory nanoparticle formulations to treat atherosclerosis
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01HL118440-01A1
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Bioorthogonal Strategies for Targeted PET Imaging Probe Development
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1K25EB016673-01
  • Funding stream: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
30 references, page 1 of 2

Mozaffarian D.. Executive summary: heart disease and stroke statistics--2016 update: a report from the American heart association. Circulation 133, 447–454 (2016).26811276 [PubMed]

Kathiresan S.. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat. Genet.41, 334–341 (2009).19198609 [OpenAIRE] [PubMed]

Swirski F. K. & Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science 339, 161–166 (2013).23307733 [OpenAIRE] [PubMed]

Weissleder R. & Nahrendorf M. Advancing biomedical imaging. Proc. Natl Acad. Sci USA. 112, 14424–14428 (2015).26598657 [OpenAIRE] [PubMed]

Weissleder R., Nahrendorf M. & Pittet M. J. Imaging macrophages with nanoparticles. Nat. Mater. 13, 125–138 (2014).24452356 [OpenAIRE] [PubMed]

Nel A. E.. Understanding biophysicochemical interactions at the nano-bio interface. Nat. Mater.8, 543–557 (2009).19525947 [PubMed]

Hilgendorf I.. Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium. Circ. Res.114, 1611–1622 (2014).24625784 [OpenAIRE] [PubMed]

Nahrendorf M.. Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury. Circulation 117, 1153–1160 (2008).18268141 [OpenAIRE] [PubMed]

Swirski F. K.. Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice. J. Clin. Invest.120, 2627–2634 (2010).20577051 [OpenAIRE] [PubMed]

Nahrendorf M.. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J. Exp. Med.204, 3037–3047 (2007).18025128 [OpenAIRE] [PubMed]

Dutta P.. Myocardial infarction accelerates atherosclerosis. Nature 487, 325–329 (2012).22763456 [OpenAIRE] [PubMed]

Vogl T.. Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity. Nat. Commun.5, 4593 (2014).25098555 [OpenAIRE] [PubMed]

Tawakol A.. Noninvasive in vivo measurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography. J. Nucl. Cardiol.12, 294–301 (2005).15944534 [PubMed]

Lee W. W.. PET/MRI of inflammation in myocardial infarction. J. Am. Coll. Cardiol.59, 153–163 (2012).22222080 [OpenAIRE] [PubMed]

Silvola J. M.. Effects of age, diet, and type 2 diabetes on the development and FDG uptake of atherosclerotic plaques. JACC Cardiovasc. Imaging 4, 1294–1301 (2011).22172786 [PubMed]

30 references, page 1 of 2
Any information missing or wrong?Report an Issue