publication . Article . Other literature type . 2011

Urine Steroid Metabolomics as a Biomarker Tool for Detecting Malignancy in Adrenal Tumors

Arlt, Wiebke; Biehl, Michael; Taylor, Angela E.; Hahner, Stefanie; Libe, Rossella; Hughes, Beverly A.; Schneider, Petra; Smith, David J.; Stiekema, Han; Krone, Nils; ...
Open Access English
  • Published: 01 Dec 2011
Abstract
Context: Adrenal tumors have a prevalence of around 2% in the general population. Adrenocortical carcinoma (ACC) is rare but accounts for 2-11% of incidentally discovered adrenal masses. Differentiating ACC from adrenocortical adenoma (ACA) represents a diagnostic challenge in patients with adrenal incidentalomas, with tumor size, imaging, and even histology all providing unsatisfactory predictive values. Objective: Here we developed a novel steroid metabolomic approach, mass spectrometry-based steroid profiling followed by machine learning analysis, and examined its diagnostic value for the detection of adrenal malignancy. Design: Quantification of 32 distinct ...
Subjects
free text keywords: ddc:616, 1, 5, Endocrine Research, Adrenocortical cancer, mitotane, TANDEM MASS-SPECTROMETRY, SUBCLINICAL CUSHINGS-SYNDROME, ADRENOCORTICAL TUMORS, COMPUTED-TOMOGRAPHY, FOLLOW-UP, INCIDENTALOMAS, DIAGNOSIS, CLASSIFICATION, CANCER, Clinical Biochemistry, Biochemistry, Endocrinology, Diabetes and Metabolism, Endocrinology, Biochemistry, medical, Pathology, medicine.medical_specialty, medicine, Adrenocortical adenoma, medicine.disease, Malignancy, Carcinoma, Metastasis, Internal medicine, business.industry, business, Biomarker (medicine), Mitotane, medicine.drug, Adrenocortical carcinoma, Population, education.field_of_study, education, Steroid, medicine.medical_treatment, Urine, Adrenal tumors, Metabolomics, Diabetes mellitus
Funded by
WT
Project
  • Funder: Wellcome Trust (WT)
,
EC| ENS@T-CANCER
Project
ENS@T-CANCER
European Network for the Study of Adrenal Tumours - Structuring clinical research on adrenal cancers in adults
  • Funder: European Commission (EC)
  • Project Code: 259735
  • Funding stream: FP7 | SP1 | HEALTH
,
RCUK| Steroid profiling as a biomarker tool in the diagnosis and monitoring of adrenal tumours
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: G0801473
  • Funding stream: MRC

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