T cell receptor alpha variable 12‐2 bias in the immunodominant response to Yellow fever virus

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Bovay, Amandine ; Zoete, Vincent ; Dolton, Garry ; Bulek, Anna M. ; Cole, David K. ; Rizkallah, Pierre J. ; Fuller, Anna ; Beck, Konrad ; Michielin, Olivier ; Speiser, Daniel E. ; Sewell, Andrew K. ; Fuertes Marraco, Silvia A. (2017)
  • Publisher: John Wiley and Sons Inc.
  • Journal: European Journal of Immunology, volume 48, issue 2, pages 258-272 (issn: 0014-2980, eissn: 1521-4141)
  • Related identifiers: pmc: PMC5887915, doi: 10.1002/eji.201747082
  • Subject: Antigen recognition | Yellow Fever virus | Germline | Research Article|Basic | Adaptive Immunity/genetics; CD8-Positive T-Lymphocytes/physiology; Cell Line; Clonal Selection, Antigen-Mediated; Clone Cells; Complementarity Determining Regions/genetics; Cytotoxicity, Immunologic; Epitopes, T-Lymphocyte/metabolism; HLA-A2 Antigen/metabolism; Humans; Immunodominant Epitopes/metabolism; Lymphocyte Activation; Receptors, Antigen, T-Cell, alpha-beta/genetics; T-Cell Antigen Receptor Specificity; Viral Proteins/metabolism; Viral Vaccines/immunology; Yellow Fever/genetics; Yellow Fever/immunology; Yellow fever virus/physiology; Antigen recognition; Germline; T cell receptor Alpha Variable (TRAV)-12-2; T cell receptor bias; Yellow Fever virus | Research Articles | Basic | T cell receptor Alpha Variable (TRAV)‐12‐2 | Adaptive immunity | T cell receptor bias

The repertoire of human αβ T-cell receptors (TCRs) is generated via somatic recombination of germline gene segments. Despite this enormous variation, certain epitopes can be immunodominant, associated with high frequencies of antigen-specific T cells and/or exhibit bias... View more
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