The Immunomodulator VacA Promotes Immune Tolerance and Persistent Helicobacter pylori Infection through Its Activities on T-Cells and Antigen-Presenting Cells

Article English OPEN
Aleksandra Djekic; Anne Müller;
  • Publisher: MDPI
  • Journal: Toxins, volume 8, issue 6 (issn: 2072-6651, eissn: 2072-6651)
  • Publisher copyright policies & self-archiving
  • Identifiers: doi: 10.3390/toxins8060187, pmc: PMC4926153
  • Subject: myeloid cells | T-cell priming | Medicine | professional antigen-presenting cells | immune tolerance | R | regulatory T-cells | Review | persistent infection | effector T-cells
    mesheuropmc: bacteria | bacterial infections and mycoses | digestive system diseases

VacA is a pore-forming toxin that has long been known to induce vacuolization in gastric epithelial cells and to be linked to gastric disorders caused by H. pylori infection. Its role as a major colonization and persistence determinant of H. pylori is less well-understo... View more
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