Synthesis of a Potent Aminopyridine-Based nNOS-Inhibitor by Two Recent No-Carrier-Added 18F-Labelling Methods

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Christian Drerup; Johannes Ermert; Heinz H. Coenen;
  • Publisher: MDPI AG
  • Journal: Molecules (issn: 1420-3049)
  • Related identifiers: doi: 10.3390/molecules21091160
  • Subject: radiopharmaceuticals | copper-mediated labelling | nNOS-inhibitor | radiofluorination | Organic chemistry | QD241-441 | iodonium ylides
    • ddc: ddc:540

Nitric oxide (NO), an important multifunctional signaling molecule, is produced by three isoforms of NO-synthase (NOS) and has been associated with neurodegenerative disorders. Selective inhibitors of the subtypes iNOS (inducible) or nNOS (neuronal) are of great interes... View more
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