Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes

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Mardinoglu A; Gogg S; Lotta LA; Stancáková A; Nerstedt A; Boren J; Blüher M; Ferrannini E; Langenberg C; Wareham NJ; Laakso M; Smith U;
  • Publisher: Elsevier BV
  • Journal: volume 27,pages151-155issn: 2352-3964, eissn: 2352-3964
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5828558, doi: 10.1016/j.ebiom.2017.12.008, doi: 10.17863/CAM.20736
  • Subject: Endothelial Cells | Microvessels | Diabetes Mellitus, Type 2 | Insulin resistance | Research Paper | Fatty Acids | Body Mass Index | 3-Hydroxyisobutyric acid (3-HIB) | T2D | Adipose Tissue | Medicine | Insulin secretion | Hydroxybutyrates | Biological Transport | R | Amino Acids, Branched-Chain | Branched-chain amino acids (BCAAs) | Humans | Incidence | Metabolome
    mesheuropmc: bacteria | bacterial infections and mycoses | health care facilities, manpower, and services | carbohydrates (lipids) | complex mixtures

Branched-chain amino acids (BCAAs) metabolite, 3-Hydroxyisobutyric acid (3-HIB) has been identified as a secreted mediator of endothelial cell fatty acid transport and insulin resistance (IR) using animal models. To identify if 3-HIB is a marker of human IR and future r... View more
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