Peroxisomes Are Required for Efficient Penicillin Biosynthesis in Penicillium chrysogenum▿ †

Article, Other literature type English OPEN
Meijer, Wiebe H.; Gidijala, Loknath; Fekken, Susan; Kiel, Jan A. K. W.; van den Berg, Marco A.; Lascaris, Romeo; Bovenberg, Roel A. L.; van der Klei, Ida J.; (2010)
  • Publisher: American Society for Microbiology (ASM)
  • Related identifiers: doi: 10.1128/AEM.02327-09, pmc: PMC2935065
  • Subject: GENE-CLUSTER | AMPLIFICATION | FILAMENTOUS FUNGI | INVOLVEMENT | PROLIFERATION | PROTEIN | ASPERGILLUS-NIDULANS | BIOGENESIS | METABOLISM | Mycology | ACYLTRANSFERASE

In the fungus Penicillium chrysogenum, penicillin (PEN) production is compartmentalized in the cytosol and in peroxisomes. Here we show that intact peroxisomes that contain the two final enzymes of PEN biosynthesis, acyl coenzyme A (CoA):6-amino penicillanic acid acyltr... View more
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