DNA Damage Induced by Alkylating Agents and Repair Pathways

Article, Review English OPEN
Kondo, Natsuko ; Takahashi, Akihisa ; Ono, Koji ; Ohnishi, Takeo (2010)
  • Publisher: SAGE-Hindawi Access to Research
  • Journal: Journal of Nucleic Acids, volume 2,010 (issn: 2090-021X, eissn: 2090-021X)
  • Related identifiers: doi: 10.4061/2010/543531, pmc: PMC2989456
  • Subject: Review Article | QH426-470 | Genetics | QD415-436 | Biochemistry | Article Subject
    mesheuropmc: congenital, hereditary, and neonatal diseases and abnormalities

The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes, necessitating a clear understanding of the repair mechanisms. Simple methylating agents form adducts at N- and O-atoms. N-methylations are removed by base excision repai... View more
Share - Bookmark