DNA Damage Induced by Alkylating Agents and Repair Pathways
- Publisher: SAGE-Hindawi Access to Research
Journal of Nucleic Acids,
(issn: 2090-021X, eissn: 2090-021X)
Review Article | QH426-470 | Genetics | QD415-436 | Biochemistry | Article Subject
mesheuropmc: congenital, hereditary, and neonatal diseases and abnormalities
The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes, necessitating a clear understanding of the repair mechanisms. Simple methylating agents form adducts at N- and O-atoms. N-methylations are removed by base excision repai...