publication . Article . Other literature type . 2008

Compromised CD4+ CD25high regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

VENKEN, Koen; HELLINGS, Niels; THEWISSEN, Marielle; SOMERS, Veerle; HENSEN, Karen; RUMMENS, Jean-Luc; MEDAER, Rob; Hupperts, Raymond; STINISSEN, Piet;
Open Access English
  • Published: 01 Jan 2008
  • Publisher: Blackwell Science Inc
Abstract
CD4(+) CD25(high) regulatory T cells (Tregs) of patients with relapsing-remitting (RR) multiple sclerosis (MS), in contrast to those of patients with secondary progressive (SP) MS, show a reduced suppressive function. In this study, we analysed forkhead box P3 (FOXP3) at the single-cell level in MS patients and controls (healthy individuals and patients with other neurological diseases) by means of intracellular flow cytometry. Our data revealed a reduced number of peripheral blood CD4(+) CD25(high) FOXP3(+) T cells and lower FOXP3 protein expression per cell in RR-MS patients than in SP-MS patients and control individuals, which was correlated...
Subjects
mesheuropmc: chemical and pharmacologic phenomenahemic and immune systems
free text keywords: Original Articles, autoimmunity; multiple sclerosis; tolerance; regulatory T cells; FOXP3
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publication . Article . Other literature type . 2008

Compromised CD4+ CD25high regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

VENKEN, Koen; HELLINGS, Niels; THEWISSEN, Marielle; SOMERS, Veerle; HENSEN, Karen; RUMMENS, Jean-Luc; MEDAER, Rob; Hupperts, Raymond; STINISSEN, Piet;