Compromised CD4(+) CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

Article, Other literature type English OPEN
VENKEN, Koen; HELLINGS, Niels; THEWISSEN, Marielle; SOMERS, Veerle; HENSEN, Karen; RUMMENS, Jean-Luc; MEDAER, Rob; Hupperts, Raymond; STINISSEN, Piet;
(2008)
  • Publisher: BLACKWELL PUBLISHING
  • Related identifiers: doi: 10.1111/j.1365-2567.2007.02690.x, pmc: PMC2433271
  • Subject: Original Articles | autoimmunity; multiple sclerosis; tolerance; regulatory T cells; FOXP3
    mesheuropmc: chemical and pharmacologic phenomena | hemic and immune systems

CD4(+) CD25(high) regulatory T cells (Tregs) of patients with relapsing-remitting (RR) multiple sclerosis (MS), in contrast to those of patients with secondary progressive (SP) MS, show a reduced suppressive function. In this study, we analysed forkhead box P3 (... View more
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