Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages.

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Zavialov, Andrey V; Gracia, Eduard; Glaichenhaus, Nicolas; Franco, Rafael; Zavialov, Anton V; Lauvau, Grégoire;
(2010)
  • Publisher: Elsevier
  • Identifiers: doi: 10.1189/jlb.1109764
  • Subject: MESH: Stromal Cells | MESH: Basic Helix-Loop-Helix Transcription Factors | [SDV.IMM]Life Sciences [q-bio]/Immunology | MESH: Gene Expression Regulation | MESH: Cell Movement | MESH: Humans | MESH: Endometrium | MESH: Homeodomain Proteins | MESH: Neovascularization, Physiologic | MESH: Cell Cycle | MESH: Membrane Proteins | MESH: Intercellular Signaling Peptides and Proteins | MESH: Calcium-Binding Proteins | MESH: Oligonucleotide Array Sequence Analysis | MESH: Cell Cycle Proteins | MESH: Receptor, Notch2 | MESH: Female | MESH: Receptor, Notch1 | MESH: Receptors, Notch | MESH: Cell Communication | MESH: Cell Adhesion

International audience; ADAs play a pivotal role in regulating the level of adenosine, a signaling molecule controlling a variety of cellular responses by binding to and activating four ADRs. Two enzymes, ADA1 and ADA2, are known to possess ADA activity in humans. Altho... View more
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