publication . Article . 2012

Relation of genetic variants of CYP2A6 with tobacco dependence and smoking habit in Chilean subjects: A pilot study

Dante D Cáceres; Sergio A Alvarado; Paulina Martínez; Luis A Quiñones;
Open Access Spanish
  • Published: 01 Apr 2012
  • Publisher: Sociedad Médica de Santiago
Abstract
Background: Genetic and metabolic factors associated with nicotine metabolism may be related to smoking behavior. Aim: To assess the prevalence of allelic and genotype variants of CYP2A6 in a sample of Chilean subjects and to evaluate their relationship with smoking and tobacco dependence. Material and Methods: The genotype frequencies for *2, *3 and *4 of CYP2A6*1 (wild type) gene were determined by polymerase chain reaction (PCR) in 54 volunteers. Addiction to tobacco was evaluated using the Fagerstrom Test. The association between the presence of allelic variants of CYP2A6 and smoking and tobacco dependence was evaluated with chi square test. Results: The pre...
Subjects
free text keywords: CYP2A6, Genetic, Polymorphisms, Protein, human, Tobacco use disorder, General Medicine, Wild type, Endocrinology, medicine.medical_specialty, medicine, business.industry, business, Chi-square test, Internal medicine, Allele, Genotype frequency, Diabetes mellitus, medicine.disease, Genotype, Polymerase chain reaction, law.invention, law
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