Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation

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Raimondi, L.; De Luca, A.; Amodio, N.; Manno, M.; Raccosta, S.; Taverna, S.; Bellavia, D.; Naselli, F.; Fontana, S.; Schillaci, O.; Giardino, R.; Fini, M.; Tassone, P.; Santoro, A.; De Leo, G.; Giavaresi, G.; Alessandro, R.;
  • Publisher: Impact Journals LLC
  • Journal: volume 6,issue 15,pages13,772-13,789eissn: 1949-2553
  • Related identifiers: pmc: PMC4537049
  • Subject: Exosomes, Multiple Myeloma; Osteoclasts; Bone Formation | multiple myeloma | exosomes | osteoclasts | tumor microenvironment | Settore BIO/13 - Biologia Applicata | Research Paper

Bone disease is the most frequent complication in multiple myeloma (MM) resulting in osteolytic lesions, bone pain, hypercalcemia and renal failure. In MM bone disease the perfect balance between bone-resorbing osteoclasts (OCs) and bone-forming osteoblasts (OBs) activi... View more
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