publication . Article . 2009

Power and false-positive rates for the restricted partition method (RPM) in a large candidate gene data set

Culverhouse Robert; Jin Wu; Jin Carol H; Hinrichs Anthony L; Suarez Brian K;
Open Access English
  • Published: 01 Dec 2009 Journal: BMC Proceedings, volume 3, issue Suppl 7, pages S74-S74 (eissn: 1753-6561, Copyright policy)
  • Publisher: BioMed Central
Abstract
<p>Abstract</p> <p>Many phenotypes of public health importance (e.g., diabetes, coronary artery disease, major depression, obesity, and addictions to alcohol and nicotine) involve complex pathways of action. Interactions between genetic variants or between genetic variants and environmental factors likely play important roles in the functioning of these pathways. Unfortunately, complex interacting systems are likely to have important interacting factors that may not readily reveal themselves to univariate analyses. Instead, detecting the role of some of these factors may require analyses that are sensitive to interaction effects.</p> <p>In this study, we evaluat...
Subjects
free text keywords: Proceedings, Medicine, R, Science, Q, General Biochemistry, Genetics and Molecular Biology, General Medicine, Biology, Bioinformatics, Candidate gene, Phenotype, Partition method, Genetic variants, Addiction, media_common.quotation_subject, media_common, Genetics
Funded by
NIH| GENETIC INTERACTIONS CONTRIBUTING TO ALCOHOL AND NICOTINE DEPENDENCE
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R03DA023166-01A1
  • Funding stream: NATIONAL INSTITUTE ON DRUG ABUSE
,
NIH| Genetic Analysis of Common Diseases: An Evaluation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM031575-22
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| Computational Methods to Detect Epistasis
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5K25GM069590-03
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

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Kraja, AT, Culverhouse, R, Daw, EW, Wu, J, van Brunt, A, Province, MA, Borecki, IB. The Genetic Analysis Workshop 16 Problem 3: simulation of heritable longitudinal cardiovascular phenotype based on actual genome-wide single-nucleotide polymorphisms in the Framingham Heart Study. BMC Proc. 2009; 3 (suppl 7): S4 [OpenAIRE]

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