The BDNF/TrkB Signaling Pathway Is Involved in Heat Hyperalgesia Mediated by Cdk5 in Rats

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Zhang, Hong-Hai; Zhang, Xiao-Qin; Xue, Qing-Sheng; Yan-Luo,; Huang, Jin-Lu; Zhang, Su; Shao, Hai-Jun; Lu, Han; Wang, Wen-Yuan; Yu, Bu-Wei;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 9,issue 1 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0085536, pmc: PMC3897472
  • Subject: Endocrine System | Research Article | Biology | Molecular Cell Biology | Growth Factors | Anesthesiology | Signal Transduction | Neurological Signaling | Neuroscience | Medicine | Pain Management | Signaling in Selected Disciplines | Anatomy and Physiology | Q | R | Proteins | Science | Endocrine Physiology | Biochemistry | Neurology
    mesheuropmc: musculoskeletal, neural, and ocular physiology | nervous system | embryonic structures

Background Cyclin-dependent kinase 5 (Cdk5) has been shown to play an important role in mediating inflammation-induced heat hyperalgesia. However, the underlying mechanism remains unclear. The aim of this study was to determine whether roscovitine, an inhibitor of Cdk5,... View more
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