publication . Article . 2003

On different approximations to multilocus identity-by-descent calculations and the resulting power of variance component-based linkage analysis

Göring, Harald HH; Williams, Jeff T; Dyer, Thomas D; Blangero, John;
Open Access English
  • Published: 01 Dec 2003 Journal: BMC Genetics, volume 4, issue Suppl 1, page S72 (issn: 1471-2156, Copyright policy)
  • Publisher: Springer Nature
Abstract
<p>Abstract</p> <p>An empirical comparison between three different methods for estimation of pair-wise identity-by-descent (IBD) sharing at marker loci was conducted in order to quantify the resulting differences in power and localization precision in variance components-based linkage analysis. On the examined simulated, error-free data set, it was found that an increase in accuracy of allele sharing calculation resulted in an increase in power to detect linkage. Linkage analysis based on approximate multi-marker IBD matrices computed by a Markov chain Monte Carlo approach was much more powerful than linkage analysis based on exact single-marker IBD probabilitie...
Subjects
free text keywords: Genetics(clinical), Genetics, QH426-470, Proceedings, Robustness (computer science), Bioinformatics, Markov chain Monte Carlo, symbols.namesake, symbols, Biology, Monte Carlo method, Identity by descent, Matrix (mathematics), Computation, Data structure, Markov chain
Funded by
NIH| Genetic Analysis of Common Diseases: An Evaluation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM031575-22
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| QUANTITATIVE TRAIT LOCUS MAPPING IN HUMAN PEDIGREES
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01MH059490-02
  • Funding stream: NATIONAL INSTITUTE OF MENTAL HEALTH
,
NIH| CORE--FIELD AND CLINIC OPERATIONS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P01HL045522-10
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
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NIH| LIPID BIOCHEMISTRY--CORE
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P01HL028972-04
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

Hopper, JL, Mathews, JD. Extensions to multivariate normal models for pedigree analysis. Ann Hum Genet. 1982; 46: 373-383 [OpenAIRE] [PubMed]

Lange, KL, Little, RJA, Taylor, JMG. Robust statistical modeling using the t distribution. J Am Stat Assoc. 1989; 84: 881-896 [OpenAIRE] [DOI]

Göring, HHH, Terwilliger, JD. Linkage analysis in the presence of errors. I: Complex-valued recombination fractions and complex phenotypes. Am J Hum Genet. 2000; 66: 1095-1106 [OpenAIRE] [PubMed] [DOI]

Göring, HHH, Terwilliger, JD. Linkage analysis in the presence of errors. II: Marker-locus genotyping errors modeled with hypercomplex recombination fractions. Am J Hum Genet. 2000; 66: 1107-1118 [OpenAIRE] [PubMed] [DOI]

Göring, HHH, Terwilliger, JD. Linkage analysis in the presence of errors. III: Marker loci and their map as nuisance parameters. Am J Hum Genet. 2000; 66: 1298-1309 [OpenAIRE] [PubMed] [DOI]

Elston, RC, Stewart, J. A general model for the analysis of pedigree data. Hum Hered. 1971; 21: 523-542 [PubMed]

Lander, ES, Green, P. Construction of multilocus genetic maps in humans. Proc Natl Acad Sci USA. 1987; 84: 2363-2367 [OpenAIRE] [PubMed] [DOI]

Sobel, E, Lange, K. Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet. 1996; 58: 1323-1337 [OpenAIRE] [PubMed]

Heath, SC. Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. Am J Hum Genet. 1997; 16: 748-760 [OpenAIRE] [PubMed]

Fulker, DW, Cardon, LR. A sib-pair approach to interval mapping of quantitative trait loci. Am J Hum Genet. 1994; 54: 1092-1103 [OpenAIRE] [PubMed]

Almasy, L, Blangero, J. Multipoint quantitative trait linkage analysis in general pedigrees. Am J Hum Genet. 1998; 62: 1198-1211 [OpenAIRE] [PubMed] [DOI]

Dawber, TR, Meadors, GF, Moore, FEJ. Epidemiological approaches to heart disease: the Framingham study. Am J Public Health. 1951; 41: 279-286 [OpenAIRE] [PubMed]

Cottingham, RW, Idury, RM, Schäffer, AA. Faster sequential genetic linkage computations. Am J Hum Genet. 1993; 53: 252-263 [OpenAIRE] [PubMed]

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