Adhesion rings surround invadopodia and promote maturation

Article English OPEN
Branch, Kevin M. ; Hoshino, Daisuke ; Weaver, Alissa M. (2012)
  • Publisher: The Company of Biologists
  • Journal: Biology Open, volume 1, issue 8, pages 711-722 (issn: 2046-6390, eissn: 2046-6390)
  • Related identifiers: doi: 10.1242/bio.20121867, pmc: PMC3507228
  • Subject: Q | Invadopodia | Research Article | Invasion | Adhesion rings | Science | ILK | MT1-MMP | Integrin | Biology (General) | QH301-705.5

Summary Invasion and metastasis are aggressive cancer phenotypes that are highly related to the ability of cancer cells to degrade extracellular matrix (ECM). At the cellular level, specialized actin-rich structures called invadopodia mediate focal matrix degradation... View more