Genetics and epigenetics of obesity

Article English OPEN
Herrera, Blanca M. ; Keildson, Sarah ; Lindgren, Cecilia M. (2011)
  • Publisher: Elsevier BV
  • Journal: Maturitas, volume 69, issue 1, pages 41-49 (issn: 0378-5122, eissn: 1873-4111)
  • Related identifiers: pmc: PMC3213306, doi: 10.1016/j.maturitas.2011.02.018
  • Subject: Genetic | Fat distribution | Imprinting | Epigenetic | CNV, copy number variants | WHR, waist:hip ratio | SNP, single nucleotide polymorphism | LD, linkage disequilibrium | QTL, quantitative trait loci | Biochemistry, Genetics and Molecular Biology(all) | Review | T2D, type-2-diabetes | Methylation | BMI, body mass index | Obstetrics and Gynaecology | WC, waist circumference | PWS, Prader–Willi syndrome | Obesity

Obesity results from interactions between environmental and genetic factors. Despite a relatively high heritability of common, non-syndromic obesity (40–70%), the search for genetic variants contributing to susceptibility has been a challenging task. Genome wide associa... View more
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