Genetics and epigenetics of obesity
Herrera, Blanca M.
Lindgren, Cecilia M.
- Publisher: Elsevier BV
(issn: 0378-5122, eissn: 1873-4111)
Genetic | Fat distribution | Imprinting | Epigenetic | CNV, copy number variants | WHR, waist:hip ratio | SNP, single nucleotide polymorphism | LD, linkage disequilibrium | QTL, quantitative trait loci | Biochemistry, Genetics and Molecular Biology(all) | Review | T2D, type-2-diabetes | Methylation | BMI, body mass index | Obstetrics and Gynaecology | WC, waist circumference | PWS, Prader–Willi syndrome | Obesity
Obesity results from interactions between environmental and genetic factors. Despite a relatively high heritability of common, non-syndromic obesity (40–70%), the search for genetic variants contributing to susceptibility has been a challenging task. Genome wide associa...