Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators

Article English OPEN
Uversky, Vladimir N.;
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Molecular Biosciences,volume 1 (issn: 2296-889X, eissn: 2296-889X)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4428494, doi: 10.3389/fmolb.2014.00006/full, doi: 10.3389/fmolb.2014.00006
  • Subject: Review Article | expression | alternative splicing | posttranslational modification | Diabetes Mellitus | Cardiovascular Diseases | transcriptional activation | QH301-705.5 | Molecular Biosciences | Neurodegenerative Diseases | conformational diseases | Cancer | proteolytic degradation | intrinsically disordered proteins | trafficking | Biology (General)

Biologically active proteins without stable tertiary structure are common in all known proteomes. Functions of these intrinsically disordered proteins (IDPs) are typically related to regulation, signaling, and control. Cellular levels of these important regulators are t... View more
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