publication . Article . Other literature type . 2014

Oral Immunization Against Candidiasis Using Lactobacillus casei Displaying Enolase 1 from Candida albicans

SHIBASAKI, Seiji; KARASAKI, Miki; TAFUKU, Senji; AOKI, Wataru; SEWAKI, Tomomitsu; UEDA, Mitsuyoshi;
Open Access English
  • Published: 01 Jul 2014 Journal: Scientia Pharmaceutica, volume 82, issue 3, pages 697-708 (issn: 0036-8709, eissn: 2218-0532, Copyright policy)
  • Publisher: Scientia Pharmaceutica
Abstract
Abstract Candidiasis is a common fungal infection that is prevalent in immunocompromised individuals. In this study, an oral vaccine against Candida albicans was developed by using the molecular display approach. Enolase 1 protein (Eno1p) of C. albicans was expressed on the Lactobacillus casei cell surface by using poly-gamma-glutamic acid synthetase complex A from Bacillus subtilis as an anchoring protein. The Eno1p-displaying L. casei cells were used to immunize mice, which were later challenged with a lethal dose of C. albicans. The data indicated that the vaccine elicited a strong IgG response and increased the survival rate of the vaccinated mice. Furthermo...
Subjects
mesheuropmc: food and beverages
free text keywords: Research Article, </i>Molecular display technology, Molecular display technology, Eno1p, Lactococcus casei, <i>Candida albicans, Candidiasis, Candida albicans
35 references, page 1 of 3

Clin Microbiol Rev. 2007; 20: 133-163.

http://dx.doi.org/10.1128/CMR.00029-06

Microbiol Mol Biol Rev. 2003; 67: 400-428.

http://dx.doi.org/10.1128/MMBR.67.3.400-428.2003

J Clin Microbiol. 1996; 34: 2497-2499.

http://www.ncbi.nlm.nih.gov/pubmed/8880507

J Infect Dis. 2001; 184: 1489-1493.

http://dx.doi.org/10.1086/324532

Annu Rev Genet. 2007; 41: 193-211.

http://dx.doi.org/10.1146/annurev.genet.41.042007.170146

Med Mycol. 2004; 42: 319-324.

http://dx.doi.org/10.1080/13693780310001644653

Clin Vaccine Immunol. 2011; 18: 1656-1667.

http://dx.doi.org/10.1128/CVI.05215-11

Evaluation of Mdh1 protein as an antigenic candidate of a vaccine against candidiasis.

35 references, page 1 of 3
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publication . Article . Other literature type . 2014

Oral Immunization Against Candidiasis Using Lactobacillus casei Displaying Enolase 1 from Candida albicans

SHIBASAKI, Seiji; KARASAKI, Miki; TAFUKU, Senji; AOKI, Wataru; SEWAKI, Tomomitsu; UEDA, Mitsuyoshi;