A Genetic Screen for Mutants with Supersized Lipid Droplets in Caenorhabditis elegans

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Shiwei Li; Shibin Xu; Yanli Ma; Shuang Wu; Yu Feng; Qingpo Cui; Lifeng Chen; Shuang Zhou; Yuanyuan Kong; Xiaoyu Zhang; Jialei Yu; Mengdi Wu; Shaobing O. Zhang;
  • Publisher: Genetics Society of America
  • Journal: G3: Genes,volume 6,issue 8,pages2,407-2,419 (issn: 2160-1836, eissn: 2160-1836)
  • Related identifiers: pmc: PMC4978895, doi: 10.1534/g3.116.030866
  • Subject: C. elegans | lipid droplet | drop | QH426-470 | Genetics | forward genetic screen | Investigations | peroxisome

To identify genes that regulate the dynamics of lipid droplet (LD) size, we have used the genetically tractable model organism Caenorhabditis elegans, whose wild-type LD population displays a steady state of size with an upper limit of 3 μm in diameter. From a saturated... View more
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