Etude du rôle de l’expression du récepteur Neuropiline-1 et de l’exocytose Calcium-dépendante dans le neurone à GnRH sur le développement et la maturation du système à GnRH et la physiologie de la reproduction

Doctoral thesis French OPEN
Vanacker , Charlotte (2015)
  • Publisher: HAL CCSD
  • Subject: Syndrome de Kallmann | Kallmann syndrome | Neuroendocrinologie | Gonadotropin-releasing hormon (GnRH) | Puberté | Sémaphorines | Gonadolibérine | Exocytose | Toxines botuliques | Puberty | Migration axophilique | [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology | Hypothalamus
    mesheuropmc: endocrine system | hormones, hormone substitutes, and hormone antagonists

Fertility in mammals is the result of a long development and maturation process of the hypothalamic-pituitary-gonadal axis. The reproductive function is orchestrated by a small population of neurons, located in preoptic area of hypothalamus in rodents, and releasing in ... View more
  • References (43)
    43 references, page 1 of 5

    1. Vanacker C., Duquenne M., Messina A., Mazur D., Hrabovszky E., Pfrieger FW., Giacobini P., Prevot V. Calcium-dependent exocytosis in GnRH neurons is required for sexual maturation and body weight homeostasis but not hypothalamic targeting in female mice. Endocrinology. Révision favorable.

    2. Bellefontaine N., Chachlaki K., Parkash J., Vanacker C., Colledge W., d'Anglemont de Tassigny X., Garthwaite J., Bouret SG., Prevot V. (2014) Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction. J Clin Invest. 124(6):2550-2559.

    3. Giacobini P., Parkash J., Campagne C., Messina A., Casoni F., Vanacker C., Langlet F., Hobo B., Cagnoni G., Hanchate NK., Mazur D., Taniguchi M., Mazzone M., Verhaagen J., Ciofi P., Bouret SG., Tamagnone L., Prevot V. (2014) Semaphorin 3A is an Endothelial-cell-derived factor that controls GnRH axon growth in the adult brain. PLoS Biol. 2014 Mar 11;12(3):e1001808.

    4. Osterstock G., El Yandouzi T., Romano N., Carmignac D., Langlet F., Coutry N., Guillou A., Schaeffer M., Chauvet N., Vanacker C., Galibert E., Dehouck B., Robinson IC., Prévot V., Mollard P., Plesnila N., Méry PF. (2014) Sustained Alterations of hypothalamic tanycytes during post traumatic hypopituitarism in male mice. Endocrinology. 155(5):1887-1898.

    5. Hanchate NK., Giacobini P., Lhuillier P., Parkash J., Espy C., Fouveaut C., Leroy C., Baron S., Campagne C., Vanacker C., Collier F., Cruaud C., Meyer V., García-Piñero A., Dewailly D., Cortet-Rudelli C., Gersak K., Metz C., Chabrier G., Pugeat M., Young J., Hardelin JP., Prevot V., Dodé C. (2012) SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome. PLoS Genet. 8(8):e1002896.

    1. Vanacker C., Casoni F., Messina A., Hanchate NK., Croizier S., Bouret SG., Giacobini P., Prevot V. GnRH neuronal migration and central precocious puberty : a role for Neuropilin-1 expression in GnRH neurons. En préparation.

    21. De Seranno S, Estrella C, Loyens A, Cornea A, Ojeda SR, et al. (2004) Vascular endothelial cells promote acute plasticity in ependymoglial cells of the neuroendocrine brain. JNeurosci 24: 10353-10363.

    22. Adams RH, Lohrum M, Klostermann A, Betz H, Puschel AW (1997) The chemorepulsive activity of secreted semaphorins is regulated by furin-dependent proteolytic processing. EMBO J 16: 6077-6086.

    23. Prevot V, Croix D, Bouret S, Dutoit S, Tramu G, et al. (1999) Definitive evidence for the existence of morphological plasticity in the external zone of the median eminence during the rat estrous cycle: implication of neuro-glio-endothelial interactions in gonadotropin-releasing hormone release. Neuroscience 94: 809-819.

    24. Christian CA, Moenter SM (2010) The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges. Endocr Rev 31: 544-577.

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