A Staphylococcus xylosus Isolate with a New mecC Allotype

Article, Other literature type OPEN
Harrison, Ewan M.; Paterson, Gavin K.; Holden, Matthew T. G.; Morgan, Fiona J. E.; Larsen, Anders Rhod; Petersen, Andreas; Leroy, Sabine; De Vliegher, Sarne; Perreten, Vincent; Fox, Lawrence K.; Lam, Theo J. G. M.; Sampimon, Otlis C.; Zadoks, Ruth N.; Peacock, Sharon J.; Parkhill, Julian; Holmes, Mark A.;
(2013)
  • Publisher: American Society for Microbiology
  • Related identifiers: pmc: PMC3591899, doi: 10.7892/boris.43804, doi: 10.1128/AAC.01882-12
  • Subject: Bacterial Proteins | Bacterial Typing Techniques | Methicillin Resistance | Anti-Bacterial Agents | Sequence Homology, Amino Acid | Transcription Factors | Cattle | Methicillin-Resistant Staphylococcus aureus | Genetic Loci | Mechanisms of Resistance | Genome, Bacterial | Protein Isoforms | Sequence Analysis, DNA | Staphylococcus | 630 Agriculture | Animals | Humans
    mesheuropmc: bacterial infections and mycoses | biochemical phenomena, metabolism, and nutrition | body regions

Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome ... View more
  • References (31)
    31 references, page 1 of 4

    1. Hartman BJ, Tomasz A. 1984. Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. J. Bacteriol. 158:513-516.

    2. Lim D, Strynadka NC. 2002. Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Nat. Struct. Biol. 9:870 - 876.

    3. Ubukata K, Nonoguchi R, Matsuhashi M, Konno M. 1989. Expression and inducibility in Staphylococcus aureus of the mecA gene, which encodes a methicillin-resistant S. aureus-specific penicillin-binding protein. J. Bacteriol. 171:2882-2885.

    4. Fuda C, Suvorov M, Vakulenko SB, Mobashery S. 2004. The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. J. Biol. Chem. 279:40802- 40806.

    5. Garcia-Alvarez L, Holden MT, Lindsay H, Webb CR, Brown DF, Curran MD, Walpole E, Brooks K, Pickard DJ, Teale C, Parkhill J, Bentley SD, Edwards GF, Girvan EK, Kearns AM, Pichon B, Hill RL, Larsen AR, Skov RL, Peacock SJ, Maskell DJ, Holmes MA. 2011. Methicillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. Lancet Infect. Dis. 11:595- 603.

    6. Paterson GK, Larsen AR, Robb A, Edwards GE, Pennycott TW, Foster G, Mot D, Hermans K, Baert K, Peacock SJ, Parkhill J, Zadoks RN, Holmes MA. 2012. The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolates from a diverse range of host species. J. Antimicrob. Chemother. 67:2809 -2813.

    7. Cuny C, Layer F, Strommenger B, Witte W. 2011. Rare occurrence of methicillin-resistant Staphylococcus aureus CC130 with a novel mecA homologue in humans in Germany. PLoS One 6:e24360. doi:10.1371 /journal.pone.0024360.

    8. Shore AC, Deasy EC, Slickers P, Brennan G, O'Connell B, Monecke S, Ehricht R, Coleman DC. 2011. Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillinresistant Staphylococcus aureus. Antimicrob. Agents Chemother. 55:3765- 3773.

    9. Kriegeskorte A, Ballhausen B, Idelevich EA, Kock R, Friedrich AW, Karch H, Peters G, Becker K. 2012. Human MRSA isolates with novel genetic homolog, Germany. Emerg. Infect. Dis. 18:1016 -1018.

    10. Sabat AJ, Koksal M, Akkerboom V, Monecke S, Kriegeskorte A, Hendrix R, Ehricht R, Kock R, Becker K, Friedrich AW. 2012. Detection of new methicillin-resistant Staphylococcus aureus that carry novel genetic homologue and important virulence determinants. J. Clin. Microbiol. 50: 3374 -3377.

  • Related Research Results (1)
  • Related Organizations (9)
  • Metrics
Share - Bookmark