Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis

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Letouzé, Eric; Shinde, Jayendra; Renault, Victor; Couchy, Gabrielle; Blanc, Jean-Frédéric; Tubacher, Emmanuel; Bayard, Quentin; Bacq, Delphine; Meyer, Vincent; Semhoun, Jérémy; Bioulac-Sage, Paulette; Prévôt, Sophie; Azoulay, Daniel; Paradis, Valérie; Imbeaud, Sandrine; Deleuze, Jean-François; Zucman-Rossi, Jessica;

(2017)

Publisher: Nature Publishing Group UK

Journal: Nature Communications,volume 8 (issn: 2041-1723, eissn: 2041-1723)

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Related identifiers: pmc: PMC5670220, doi: 10.1038/s41467-017-01358-x
Subject: Q | Science | Article

Genomic alterations driving tumorigenesis result from the interaction of environmental exposures and endogenous cellular processes. With a diversity of risk factors, liver cancer is an ideal model to study these interactions. Here, we analyze the whole genomes of 44 new... View more

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Related Research Results (3)

Inferred by OpenAIRE

software bam-readcount software on GitHub in support of 'The effects of transcription and recombination on mutational dynamics of short tandem repeats'	72%
software cgpBattenberg software on GitHub in support of 'Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal'	72%
software Palimpsest software on GitHub	72%

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dataset Whole Genome Sequencing of Liver Cancers	78%
dataset EGAS00001002408 - samples	75%