Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis

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Letouzé, Eric; Shinde, Jayendra; Renault, Victor; Couchy, Gabrielle; Blanc, Jean-Frédéric; Tubacher, Emmanuel; Bayard, Quentin; Bacq, Delphine; Meyer, Vincent; Semhoun, Jérémy; Bioulac-Sage, Paulette; Prévôt, Sophie; Azoulay, Daniel; Paradis, Valérie; Imbeaud, Sandrine; Deleuze, Jean-François; Zucman-Rossi, Jessica;

Genomic alterations driving tumorigenesis result from the interaction of environmental exposures and endogenous cellular processes. With a diversity of risk factors, liver cancer is an ideal model to study these interactions. Here, we analyze the whole genomes of 44 new... View more
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