Detailed simulation of cancer exome sequencing data reveals differences and common limitations of variant callers

Article, Other literature type English OPEN
Hofmann, Ariane L.; Behr, Jonas; Singer, Jochen; Kuipers, Jack; Beisel, Christian; Schraml, Peter; Moch, Holger; Beerenwinkel, Niko;

Background Next-generation sequencing of matched tumor and normal biopsy pairs has become a technology of paramount importance for precision cancer treatment. Sequencing costs have dropped tremendously, allowing the sequencing of the whole exome of tumors for just a fra... View more