A Combined Metabolomic and Proteomic Analysis of Gestational Diabetes Mellitus

Other literature type, Article English OPEN
Hajduk, Joanna; Klupczynska, Agnieszka; Dereziński, Paweł; Matysiak, Jan; Kokot, Piotr; Nowak, Dorota M.; Gajęcka, Marzena; Nowak-Markwitz, Ewa; Kokot, Zenon J.;
  • Publisher: Multidisciplinary Digital Publishing Institute
  • Journal: International Journal of Molecular Sciences,volume 16,issue 12,pages30,034-30,045 (issn: 1422-0067, eissn: 1422-0067)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4691080, doi: 10.3390/ijms161226133
  • Subject: Chemistry | chemometric analysis | combined metabolomic and proteomic approach | QD1-999 | mass spectrometry | gestational diabetes mellitus | Article | Biology (General) | QH301-705.5

The aim of this pilot study was to apply a novel combined metabolomic and proteomic approach in analysis of gestational diabetes mellitus. The investigation was performed with plasma samples derived from pregnant women with diagnosed gestational diabetes mellitus (n = 1... View more
  • References (15)
    15 references, page 1 of 2

    N. Engl. J. Med. 2009, 361, 1339-1348. [CrossRef] [PubMed] 10. Lain, K.Y.; Daftary, A.R.; Ness, R.B.; Roberts, J.M. First trimester adipocytokine concentrations and risk 11. Thadhani, R.; Powe, C.E.; Tjoa, M.L.; Khankin, E.; Ye, J.; Ecker, J.; Schneyer, A.; Karumanchi, S.A.

    First-trimester follistatin-like-3 levels in pregnancies complicated by subsequent gestational diabetes mellitus. Diabetes Care 2010, 33, 664-669. [CrossRef] [PubMed] 12. Thadhani, R.; Wolf, M.; Hsu-Blatman, K.; Sandler, L.; Nathan, D.; Ecker, J.L. First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus. Am. J. Obstet. Gynecol. 2003, 189, 171-176.

    [CrossRef] [PubMed] 13. Spencer, K.; Yu, C.K.H.; Rembouskos, G.; Bindra, R.; Nicolaides, K.H. First trimester sex hormone-binding globulin and subsequent development of preeclampsia or other adverse pregnancy outcomes.

    Hypertens. Pregnancy 2005, 24, 303-311. [CrossRef] [PubMed] 14. Nanda, S.; Savvidou, M.; Syngelaki, A.; Akolekar, R.; Nicolaides, K.H. Prediction of gestational diabetes mellitus by maternal factors and biomarkers at 11 to 13 weeks. Prenat. Diagn. 2011, 31, 135-141. [CrossRef] [PubMed] 15. Kim, S.M.; Park, J.S.; Norwitz, E.R.; Lee, S.M.; Kim, B.J.; Park, C.W.; Jun, J.K.; Kim, C.W.; Syn, H.C.

    Identification of proteomic biomarkers in maternal plasma in the early second trimester that predict the subsequent development of gestational diabetes. Reprod. Sci. 2012, 19, 202-209. [CrossRef] [PubMed] 16. Liu, B.; Xu, Y.; Voss, C.; Qiu, F.H.; Zhao, M.Z.; Liu, Y.D.; Nie, J.; Wang, Z.L. Altered protein expression in gestational diabetes mellitus placentas provides insight into insulin resistance and coagulation/fibrinolysis pathways. PLoS ONE 2012, 7, e44701. [CrossRef] [PubMed] 17. Marroqui, L.; Alonso-Magdalena, P.; Merino, B.; Fuentes, E.; Nadal, A.; Quesada, I. Nutrient regulation of glucagon secretion: Involvement in metabolism and diabetes. Nutr. Res. Rev. 2014, 27, 48-62. [CrossRef] [PubMed] 18. Newsholme, P.; Cruzat, V.; Arfuso, F.; Keane, K. Nutrient regulation of insulin secretion and action.

    J. Endocrinol. 2014, 221, R105-R120. [CrossRef] [PubMed] 19. Wang, T.J.; Larson, M.G.; Vasan, R.S.; Cheng, S.; Rhee, E.P.; McCabe, E.; Lewis, G.D.; Fox, C.S.; Jacques, P.F.; Fernandez, C.; et al. Metabolite profiles and the risk of developing diabetes. Nat. Med. 2011, 17, 448-453.

    [CrossRef] [PubMed] 20. Cetin, I.; de Santis, M.S.; Taricco, E.; Radaelli, T.; Teng, C.; Ronzoni, S.; Spada, E.; Milani, S.; Pardi, G.

    Maternal and fetal amino acid concentrations in normal pregnancies and in pregnancies with gestational diabetes mellitus. Am. J. Obstet. Gynecol. 2005, 192, 610-617. [CrossRef] [PubMed] 21. Kalkhoff, R.K.; Kandaraki, E.; Morrow, P.G.; Mitchell, T.H.; Kelber, S.; Borkowf, H.I. Relationship between neonatal birth-weight and maternal plasma amino-acid profiles in lean and obese nondiabetic women and in type-I diabetic pregnant-women. Metabolism 1988, 37, 234-239. [CrossRef] 22. Mochida, T.; Tanaka, T.; Shiraki, Y.; Tajiri, H.; Matsumoto, S.; Shimbo, K.; Ando, T.; Nakamura, K.; Okamoto, M.; Endo, F. Time-dependent changes in the plasma amino acid concentration in diabetes mellitus. Mol. Genet. Metab. 2011, 103, 406-409. [CrossRef] [PubMed] 23. Friedrich, N. Metabolomics in diabetes research. J. Endocrinol. 2012, 215, 29-42. [CrossRef] [PubMed] 24. De Luca, G.; Calpona, P.R.; Caponetti, A.; Macaione, V.; di Benedetto, A.; Cucinotta, D.; di Giorgio, R.M.

    Preliminary report-Amino acid profile in platelets of diabetic patients. Metabolism 2001, 50, 739-741.

    [CrossRef] [PubMed] 25. Murri, M.; Insenser, M.; Bernal-Lopez, M.R.; Perez-Martinez, P.; Escobar-Morreale, H.F.; Tinahones, F.J.

  • Related Research Results (2)
  • Related Organizations (4)
  • Metrics
Share - Bookmark