Regulation of myoblast differentiation by metabolic perturbations induced by metformin

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Pavlidou, Theodora ; Rosina, Marco ; Fuoco, Claudia ; Gerini, Giulia ; Gargioli, Cesare ; Castagnoli, Luisa ; Cesareni, Gianni (2017)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 12, issue 8 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC5578649, doi: 10.1371/journal.pone.0182475
  • Subject: Myoblasts | Cell Differentiation | Research Article | Anatomy | Cyclins | Cell Cycle Inhibitors | Cell Processes | Morphogenesis | Muscles | Muscle Differentiation | Proteins | Phosphorylation | Skeletal Muscles | Cellular Types | Stem Cells | Biology and Life Sciences | Developmental Biology | Medicine | Animal Cells | Post-Translational Modification | Q | R | Cell Biology | Science | Biochemistry | Medicine and Health Sciences | Cell Cycle and Cell Division
    mesheuropmc: tissues | musculoskeletal system

The metabolic perturbation caused by calorie restriction enhances muscle repair by playing a critical role in regulating satellite cell availability and activity in the muscles of young and old mice. To clarify the underlying mechanisms we asked whether myoblast replica... View more
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