Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge.

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Marshall B Elam ; Gipsy Majumdar ; Khyobeni Mozhui ; Ivan C Gerling ; Santiago R Vera ; Hannah Fish-Trotter ; Robert W Williams ; Richard D Childress ; Rajendra Raghow
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 12, issue 8 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC5542661, doi: 10.1371/journal.pone.0181308
  • Subject: Energy-Producing Organelles | Computational Biology | Research Article | Diagnostic Medicine | Myalgia | Anatomy | Signs and Symptoms | Pathology and Laboratory Medicine | Apoptosis | Cell Processes | Genetics | Muscles | Gene Regulatory Networks | Bioenergetics | Pharmacology | Skeletal Muscles | Pain | Biology and Life Sciences | Cell Death | Drugs | Mitochondria | Musculoskeletal System | Medicine | Q | R | Cell Biology | Gene Regulation | Cellular Structures and Organelles | Statins | Biochemistry | Science | Medicine and Health Sciences | Gene Expression
    mesheuropmc: nutritional and metabolic diseases | lipids (amino acids, peptides, and proteins) | cardiovascular diseases

Statins, the 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase inhibitors, are widely prescribed for treatment of hypercholesterolemia. Although statins are generally well tolerated, up to ten percent of statin-treated patients experience myalgia symptoms, defined as musc... View more
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