Cocaine-conditioned odor cues without chronic exposure: Implications for the development of addiction vulnerability

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Lowen, Steven B.; Rohan, Michael L.; Gillis, Timothy E.; Thompson, Britta S.; Wellons, Clara B.W.; Andersen, Susan L.;
(2015)
  • Publisher: Elsevier
  • Journal: NeuroImage : Clinical,volume 8,pages652-659 (issn: 2213-1582, eissn: 2213-1582)
  • Related identifiers: doi: 10.1016/j.nicl.2015.06.012., doi: 10.1016/j.nicl.2015.06.012, pmc: PMC4788503
  • Subject: Development | Cocaine | fMRI, functional magnetic resonance imaging | PFC, prefrontal cortex | Odor | BLA, basolateral amygdala | D1 | DSTR, dorsal striatum | VTA, ventral tegmental area | Cue | BOLD, blood oxygenation level determination | Striatum | NAc, nucleus accumbens | SNc/r, substantia nigra pars compacta/reticulata | Regular Article | pharmacoMRI, pharmacological magnetic resonance imaging | ROI, region of interest

Adolescents are highly vulnerable to addiction and are four times more likely to become addicted at first exposure than at any other age. The dopamine D1 receptor, which is typically overexpressed in the normal adolescent prefrontal cortex, is involved in drug cue respo... View more
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