Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding

Article, Other literature type English OPEN
Kleiman, Laura B. ; Maiwald, Thomas ; Conzelmann, Holger ; Lauffenburger, Douglas A. ; Sorger, Peter K. (2011)
  • Publisher: Elsevier BV
  • Journal: Molecular Cell, volume 43, issue 5, pages 723-737 (issn: 1097-2765)
  • Related identifiers: doi: 10.1016/j.molcel.2011.07.014, pmc: PMC3222462
  • Subject: Molecular Biology | Cell Biology | Article
    mesheuropmc: skin and connective tissue diseases

Epidermal growth factor receptors (ErbB1–4) are oncogenic receptor tyrosine kinases (RTKs) that regulate diverse cellular processes. In this study, we combine measurement and mathematical modeling to quantify phospho-turnover at ErbB receptors in human cells and to dete... View more
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