Pathologies des hélicases et vieillissement précoce : modèle d'étude par dérivation de cellules souches pluripotentes induites (iPS)

Doctoral thesis French OPEN
Gatinois , Vincent (2017)
  • Publisher: HAL CCSD
  • Subject: Stem Cells | Cellules souches | Ipsc | Telomere | Helicase | Ips | [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology | Instabilité chromosomique | Chromosome instability
    mesheuropmc: congenital, hereditary, and neonatal diseases and abnormalities | nutritional and metabolic diseases

Helicases process the double-stranded DNA dissociation. They are involved in replication, DNA repair and maintenance of telomeres. In human, 3 helicases display mutations responsible for clinical syndromes: WRN for the Werner syndrome, BLM for the Bloom syndrome and REC... View more
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