Safety and Immunogenicity of Heterologous Prime-Boost Immunisation with Plasmodium falciparum Malaria Candidate Vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in Healthy Gambian and Kenyan Adults

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Ogwang, Caroline; Afolabi, Muhammed; Kimani, Domtila; Jagne, Ya Jankey; Sheehy, Susanne H.; Bliss, Carly M.; Duncan, Christopher J. A.; Collins, Katharine A.; Garcia Knight, Miguel A.; Kimani, Eva; Anagnostou, Nicholas A.; Berrie, Eleanor; Moyle, Sarah; Gilbert, Sarah C.; Spencer, Alexandra J.; Soipei, Peninah; Mueller, Jenny; Okebe, Joseph; Colloca, Stefano; Cortese, Riccardo; Viebig, Nicola K.; Roberts, Rachel; Gantlett, Katherine; Lawrie, Alison M.; Nicosia, Alfredo; Imoukhuede, Egeruan B.; Bejon, Philip; Urban, Britta C.; Flanagan, Katie L.; Ewer, Katie J.; ... view all 33 authors
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 8,issue 3 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3602521, doi: 10.1371/journal.pone.0057726
  • Subject: Research Article | Infectious Diseases | wa_395 | Immunity | Malaria | Immune Response | Plasmodium Falciparum | Immune System | Clinical Trials | Immunology | qx_135 | Biology | Vaccine Development | Tropical Diseases (Non-Neglected) | Adverse Reactions | Clinical Research Design | qw_805 | Medicine | wc_750 | Q | R | wa_115 | Drugs and Devices | Clinical Immunology | Science | Vaccination
    mesheuropmc: complex mixtures | parasitic diseases

BACKGROUND: Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified vaccinia Virus Ankara (MVA) vectored vaccines is a strategy recently shown to be capable of inducing strong cell mediated responses against several antigens from the ma... View more
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