Bcl-xL affects group a streptococcus-induced autophagy directly, by inhibiting fusion between autophagosomes and lysosomes, and indirectly, by inhibiting bacterial internalization via interaction with beclin 1-UVRAG

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Nakajima, Shintaro; Aikawa, Chihiro; Nozawa, Takashi; Minowa-Nozawa, Atsuko; Toh, Hirotaka; Nakagawa, Ichiro;
(2017)
  • Publisher: Public Library of Science
  • Journal: PLOS ONE,volume 12,issue 1 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5235370, doi: 10.1371/journal.pone.0170138
  • Subject: Cultured tumor cells | Precipitation Techniques | Research Article | Cell lines | Staining | Nuclear staining | Cell Processes | DAPI staining | Genetics | Immunoprecipitation | Light Microscopy | Autophagic Cell Death | Biology and life sciences | Non-coding RNA | Cell Death | RNA | Research and Analysis Methods | Immunostaining | Medicine | Nucleic acids | HeLa cells | Specimen Preparation and Treatment | Small interfering RNAs | Q | R | Cell Biology | Confocal Microscopy | Gene regulation | Biological cultures | Biochemistry | Science | Cell Staining | Cell cultures | Microscopy | Gene expression

Anti-apoptotic Bcl-2 and Bcl-xL are proposed to regulate starvation-induced autophagy by directly interacting with Beclin 1. Beclin 1 is also thought to be involved in multiple vesicle trafficking pathways such as endocytosis by binding to Atg14L and UVRAG. However, how... View more
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