3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation

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Okano, Takaichi ; Saegusa, Jun ; Nishimura, Keisuke ; Takahashi, Soshi ; Sendo, Sho ; Ueda, Yo ; Morinobu, Akio (2017)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports, volume 7 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: doi: 10.1038/srep42412, pmc: PMC5301239
  • Subject: Article
    mesheuropmc: chemical and pharmacologic phenomena | hemic and immune systems

Recent studies have shown that cellular metabolism plays an important role in regulating immune cell functions. In immune cell differentiation, both interleukin-17-producing T (Th17) cells and dendritic cells (DCs) exhibit increased glycolysis through the upregulation o... View more
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