PGC1α −1 Nucleosome Position and Splice Variant Expression and Cardiovascular Disease Risk in Overweight and Obese Individuals

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Tara M. Henagan; Laura K. Stewart; Laura A. Forney; Lauren M. Sparks; Neil Johannsen; Timothy S. Church;
  • Publisher: Hindawi Limited
  • Journal: PPAR Research,volume 2,014 (issn: 1687-4757, eissn: 1687-4765)
  • Related identifiers: doi: 10.1155/2014/895734, pmc: PMC4295622
  • Subject: Research Article | Article Subject | Biology (General) | QH301-705.5

PGC1α, a transcriptional coactivator, interacts with PPARs and others to regulate skeletal muscle metabolism. PGC1α undergoes splicing to produce several mRNA variants, with the NTPGC1α variant having a similar biological function to the full length PGC1α (FLPGC1α). CVD... View more
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