CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits

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Picard, Emilie; Houssier, Marianne; Bujold, Kim; Sapieha, Przemyslaw; Lubell, William; Dorfman, Allison; Racine, Julie; Hardy, Pierre; Febbraio, Maria; Lachapelle, Pierre; Ong, Huy; Sennlaub, Florian; Chemtob, Sylvain;
(2010)
  • Publisher: Impact Journals LLC
  • Journal: Aging (Albany NY),volume 2,issue 12,pages981-989 (issn: 1945-4589, eissn: 1945-4589)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3034186
  • Subject: [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] | MESH: Animals | MESH: Age Factors | MESH: Disease Models, Animal | MESH: Bruch Membrane | [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] | [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] | MESH : Animals | Bruch's membrane | MESH: Oligopeptides | MESH : Lipoproteins, LDL | MESH: Aging | MESH : Oligopeptides | MESH : Antigens, CD36 | MESH: Antigens, CD36 | MESH : Macular Degeneration | [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs | oxidized lipids | MESH: Macular Degeneration | Research Paper | age-related macular degeneration | MESH : Retinal Pigment Epithelium | MESH : Disease Models, Animal | MESH: Dietary Fats | MESH: Cells, Cultured | MESH : Age Factors | MESH: Retinal Pigment Epithelium | CD36 | MESH: Apolipoproteins E | MESH : Bruch Membrane | MESH : Apolipoproteins E | MESH: Mice | [ SDV.MHEP.OS ] Life Sciences [q-bio]/Human health and pathology/Sensory Organs | age‐related macular degeneration | MESH : Dietary Fats | MESH: Lipoproteins, LDL | MESH : Cells, Cultured | MESH: Mice, Knockout | MESH : Aging | MESH : Mice, Knockout | [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] | MESH : Mice
    mesheuropmc: genetic structures | eye diseases | lipids (amino acids, peptides, and proteins) | sense organs

International audience; Age-related macular degeneration (AMD) represents the major cause of vision loss in industrialized nations. Laminar deposits in Bruch's membrane (BM) are among the first prominent histopathologic features, along with drusen formation, and have be... View more
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