Culturing on Wharton's jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways.
- Publisher: Public Library of Science (PLoS)
(issn: 1932-6203, eissn: 1932-6203)
Stem Cells | Cellular Types | Biotechnology | Tissue Engineering | Stem Cell Niche | Research Article | Biology | Molecular Cell Biology | Regeneration | Developmental Biology | Cell Growth | Medicine | Immunity | Organism Development | Q | R | Mesenchymal Stem Cells | Clinical Immunology | Immunotherapy | Science | Immunology
Mesenchymal stem cells (MSCs) hold great therapeutic potential. However, MSCs undergo replication senescence during the in vitro expansion process. Wharton's jelly from the human umbilical cord harbors a large number of MSCs. In this study, we hypothesized that Wharton'...