Culturing on Wharton's jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways.

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Haojie Hao ; Guanghui Chen ; Jiejie Liu ; Dongdong Ti ; Yali Zhao ; Shenjun Xu ; Xiaobing Fu ; Weidong Han
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 8, issue 3 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0058314, pmc: PMC3596399
  • Subject: Stem Cells | Cellular Types | Biotechnology | Tissue Engineering | Stem Cell Niche | Research Article | Biology | Molecular Cell Biology | Regeneration | Developmental Biology | Cell Growth | Medicine | Immunity | Organism Development | Q | R | Mesenchymal Stem Cells | Clinical Immunology | Immunotherapy | Science | Immunology

Mesenchymal stem cells (MSCs) hold great therapeutic potential. However, MSCs undergo replication senescence during the in vitro expansion process. Wharton's jelly from the human umbilical cord harbors a large number of MSCs. In this study, we hypothesized that Wharton'... View more
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