Fast real-time monitoring of entacapone crystallization and characterization of polymorphs via Raman spectroscopy, statistics and SWAXS

Other literature type, Article English OPEN
Jednačak Tomislav; Hodzic Aden; Scheibelhofer Otto; Marijan Marijan; Khinast Johannes G.; Novak Predrag; (2014)
  • Publisher: Sciendo
  • Journal: Acta Pharmaceutica,volume 64,issue 1 (issn: 1330-0075, eissn: 1846-9558)
  • Related identifiers: doi: 10.2478/acph-2014-0009
  • Subject: Raman spectroscopy | Pharmaceutical industry | entacapone; in-line crystallization monitoring; multivariate analysis; polymorphism; Raman spectroscopy; SWAXS | SWAXS | polymorphism | entacapone | HD9665-9675 | in-line crystallization monitoring | multivariate analysis

Crystallization of the drug entacapone from binary solvent mixtures was monitored in situ using Raman optical probe. The recorded Raman spectra and statistical analysis, which included the principal components method and indirect hard modeling made it possible to estima... View more
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