Stem cell senescence: effects of REAC technology on telomerase-independent and telomerase-dependent pathways

Article English OPEN
Rinaldi, Salvatore ; Maioli, Margherita ; Pigliaru, Gianfranco ; Castagna, Alessandro ; Santaniello, Sara ; Basoli, V. ; Fontani, V. ; Ventura, Carlo (2014)
  • Publisher: Nature Publishing Group
  • Journal: volume 4 (eissn: 2045-2322)
  • Related identifiers: pmc: PMC4165271, doi: 10.1038/srep06373
  • Subject: REAC | STEM CELLS | AGEING | REGENERATIVE MEDICINE | RADIOFREQUENCY ELECTROMAGNETIC FIELD | BIO/10 Biochimica | Article

Decline in the gene expression of senescence repressor Bmi1, and telomerase, together with telomere shortening, underlay senescence of stem cells cultured for multiple passages. Here, we investigated whether the impairment of senescence preventing mechanisms can be effi... View more
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