publication . Article . Other literature type . 2017

In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1–34 for the treatment of osteoporosis

Williams, Allan J.; Jordan, Faron; King, Gareth; Lewis, Andrew L.; Illum, Lisbeth; Masud, Tahir; Perkins, Alan C.; Pearson, Richard G.;
Open Access
  • Published: 14 Oct 2017 Journal: International Journal of Pharmaceutics, volume 535, pages 113-119 (issn: 0378-5173, Copyright policy)
  • Publisher: Elsevier BV
  • Country: China (People's Republic of)
Abstract
Abstract Osteoporosis treatment with PTH 1–34 injections significantly reduces the incidence of bone fracture. Potential further reductions in fracture rate should be observed through nasal spray delivery to address the poor compliance associated with patient dislike of repeated PTH 1–34 subcutaneous injections. In vitro human osteoblast-like Saos-2 cell intracellular cAMP levels were used to define PTH 1–34 nasal spray formulation bioactivity. The chemically synthesised PTH 1–34 had an EC 50 of 0.76 nM. Absorption enhancers polyethylene glycol (15)-hydroxystearate (Solutol ® HS15), poloxamer 407, chitosan or sodium hyaluronate did not diminish the bioactivity o...
Subjects
free text keywords: Cmax, Subcutaneous injection, Pharmacology, Nasal Absorption, Poloxamer 407, medicine.drug, medicine, Nasal spray, medicine.medical_treatment, Chemistry, Nasal administration, Parathyroid hormone, Pharmacokinetics, Endocrinology, medicine.medical_specialty, Internal medicine, Osteoporosis, teriparatide, formulation, nasal spray, osteoblast, drug delivery
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publication . Article . Other literature type . 2017

In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1–34 for the treatment of osteoporosis

Williams, Allan J.; Jordan, Faron; King, Gareth; Lewis, Andrew L.; Illum, Lisbeth; Masud, Tahir; Perkins, Alan C.; Pearson, Richard G.;