Phase Ia Clinical Evaluation of the Safety and Immunogenicity of the Plasmodium falciparum Blood-Stage Antigen AMA1 in ChAd63 and MVA Vaccine Vectors

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Sheehy, Susanne H.; Duncan, Christopher J. A.; Elias, Sean C.; Biswas, Sumi; Collins, Katharine A.; O'Hara, Geraldine A.; Halstead, Fenella D.; Ewer, Katie J.; Mahungu, Tabitha; Spencer, Alexandra J.; Miura, Kazutoyo; Poulton, Ian D.; Dicks, Matthew D. J.; Edwards, Nick J.; Berrie, Eleanor; Moyle, Sarah; Colloca, Stefano; Cortese, Riccardo; Gantlett, Katherine; Long, Carole A.; Lawrie, Alison M.; Gilbert, Sarah C.; Doherty, Tom; Nicosia, Alfredo; Hill, Adrian V. S.; Draper, Simon J.;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 7,issue 2 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0031208, pmc: PMC3283618
  • Subject: Research Article | Biology | Tropical Diseases (Non-Neglected) | Clinical Research Design | Infectious Diseases | Microbiology | Medicine | Immunity | Malaria | Q | R | Clinical Immunology | Science | Parastic Protozoans | Protozoology | Vaccination
    mesheuropmc: complex mixtures | parasitic diseases

BACKGROUND: Traditionally, vaccine development against the blood-stage of Plasmodium falciparum infection has focused on recombinant protein-adjuvant formulations in order to induce high-titer growth-inhibitory antibody responses. However, to date no such vaccine encodi... View more