TIG3: An Important Regulator of Keratinocyte Proliferation and Survival

Article English OPEN
Scharadin, Tiffany M.; Eckert, Richard L.;
  • Publisher: Elsevier BV
  • Journal: Journal of Investigative Dermatology,volume 134,issue 7,pages1,811-1,816 (issn: 0022-202X, eissn: 1523-1747)
  • Related identifiers: doi: 10.1038/jid.2014.79, pmc: PMC4057967
  • Subject: Molecular Biology | Cell Biology | Dermatology | keratinocyte | tazarotene | TIG3 | Biochemistry | tumor suppressor | H-rev107 | centrosome | Article | epidermis

Tazarotene induced gene 3 (TIG3) is a tumor suppressor protein. In normal human epidermis, TIG3 is present in the differentiated, suprabasal layers and regulates terminal differentiation. TIG3 level is reduced in hyperproliferative diseases, including psoriasis and skin... View more
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