publication . Article . 2013

Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway

Gutiérrez Martínez, Enric; Fernández Ulibarri, Inés; Lázaro Diégez, Francisco; Johannes, Ludger; Pyne, Susan; Sarri Plans, Elisabet; Egea Guri, Gustavo;
Open Access English
  • Published: 16 Apr 2013
  • Publisher: The Company of Biologists
Abstract
The inhibition of phosphatidic acid phosphatase (PAP) activity by propanolol indicates that diacylglycerol (DAG) is required for the formation of transport carriers at the Golgi and for retrograde trafficking to the ER. Here we report that the PAP2 family member lipid phosphate phosphatase 3 (LPP3, also known as PAP2b) localizes in compartments of the secretory pathway from ER export sites to the Golgi complex. The depletion of human LPP3: (i) reduces the number of tubules generated from the ER-Golgi intermediate compartment and the Golgi, with those formed from the Golgi being longer in LPP3-silenced cells than in control cells; (ii) impairs the Rab6-dependent ...
Subjects
free text keywords: Homeostasis, Lípids, Lipids, Aparell de Golgi, Homeòstasi, Reticle endoplasmàtic, Golgi apparatus, Endoplasmic reticulum
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2013

Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway

Gutiérrez Martínez, Enric; Fernández Ulibarri, Inés; Lázaro Diégez, Francisco; Johannes, Ludger; Pyne, Susan; Sarri Plans, Elisabet; Egea Guri, Gustavo;