CopywriteR: DNA copy number detection from off-target sequence data.

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Kuilman, Thomas; Velds, Arno; Kemper, Kristel; Ranzani, Marco; Bombardelli, Lorenzo; Hoogstraat, Marlous; Nevedomskaya, Ekaterina; Xu, Guotai; de Ruiter, Julian; Lolkema, Martijn P; Ylstra, Bauke; Jonkers, Jos; Rottenberg, Sven; Wessels, Lodewyk F; Adams, David J; Peeper, Daniel S; Krijgsman, Oscar;
(2015)

Current methods for detection of copy number variants (CNV) and aberrations (CNA) from targeted sequencing data are based on the depth of coverage of captured exons. Accurate CNA determination is complicated by uneven genomic distribution and non-uniform capture efficie... View more
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