Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined “Complementary Lethality”

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Rytelewski, Mateusz; Ferguson, Peter J; Vareki, Saman Maleki; Figueredo, Rene; Vincent, Mark; Koropatnick, James;

A high mutation rate leading to tumor cell heterogeneity is a driver of malignancy in human cancers. Paradoxically, however, genomic instability can also render tumors vulnerable to therapeutic attack. Thus, targeting DNA repair may induce an intolerable level of DNA da... View more
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