Stability of the resistance to the thiosemicarbazone derived from 5,6-dimethoxy-1-indanone, a non-nucleoside polymerase inhibitor of bovine viral diarrhea virus.

Article English OPEN
Eliana F Castro; Rodolfo H Campos; Lucía V Cavallaro;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 9,issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC4065067, doi: 10.1371/journal.pone.0100528
  • Subject: Microbial Control | Antivirals | Research Article | Veterinary Diseases | Veterinary Virology | BVDV | Pathology and Laboratory Medicine | Microbial Evolution | Antimicrobials | Host-Pathogen Interactions | Evolutionary Biology | Virología | THIOSEMICARBAZONE | Viral Evolution | Ciencias Biológicas | Biology and Life Sciences | Organismal Evolution | Veterinary Science | Microbiology | Medicine | EVOLUTION | RESISTANCE | CIENCIAS NATURALES Y EXACTAS | Viral Replication | Pathogenesis | Q | R | Virology | Science | Medicine and Health Sciences

Bovine viral diarrhea virus (BVDV) is the prototype Pestivirus. BVDV infection is distributed worldwide and causes serious problems for the livestock industry. The thiosemicarbazone of 5,6-dimethoxy-1-indanone (TSC) is a non-nucleoside polymerase inhibitor (NNI) of BVDV... View more