STAT3-RXR-Nrf2 activates systemic redox and energy homeostasis upon steep decline in pO2 gradient

Article English OPEN
Subhojit Paul; Anamika Gangwar; Kalpana Bhargava; Yasmin Ahmad;
(2018)
  • Publisher: Elsevier
  • Journal: Redox Biology,volume 14,pages423-438 (issn: 2213-2317, eissn: 2213-2317)
  • Related identifiers: doi: 10.1016/j.redox.2017.10.013, pmc: PMC5680518
  • Subject: Hypoxia | pO2 gradient | Nrf2 | Cytoskeleton | R5-920 | Redox homeostasis | RXR | QH301-705.5 | STAT3 | Medicine (General) | Network biology | Research Paper | Energy homeostasis | Biology (General)

Hypobaric hypoxia elicits several patho-physiological manifestations, some of which are known to be lethal. Among various molecular mechanisms proposed so far, perturbation in redox state due to imbalance between radical generation and antioxidant defence is promising. ... View more
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